CBD Oil for Pain: Research, Potential Benefits and Top Best CBD Oil Products for 2020

Written by Zora Degrandpre, MS, ND & Gleb Oleinik, CBD Journalist
Last Updated
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* Statements regarding CBD products have not been evaluated by the Food and Drug Administration.
* Please advise your physician prior to each use of CBD.

Pain is one of the most common reasons people turn to CBD. Unlike prescription painkillers, which are rife with serious side effects and the potential for dependence and withdrawal, CBD is a safe, natural substance.

Check out our best CBD oil products list

Read our “CBD oil for pain” in depth guide to understand if CBD Oil can really help relieve pain?

Having said that, there isn’t yet enough evidence to substantiate CBD’s pain-relieving effects and most of the findings are restricted to animal studies. For now, research suggests that cannabinoids and cannabis as a whole may help relieve various types of pain. Most notably, a 2015 review that analyzed the findings of 28 separate clinical studies found that “There was moderate-quality evidence to support the use of cannabinoids for the treatment of chronic pain.” As such, more human trials looking specifically at CBD are needed.

The lack of conclusive research evidence hasn’t stopped millions of people from trying CBD products to relieve pain, aches, soreness, inflammation, and other types of physical discomfort.

It’s important to note that all types of CBD products can help with pain and not just formulas with a specific method of application or additional ingredients. However, with thousands of available CBD products, finding the right one to address your pain can be challenging.

For example, a person with severe pain will require a higher-potency formulation to experience relief than someone with minor aches. Similarly, a formulation with additional pain-relieving ingredients, such as menthol, can be more effective than one made with pure CBD.

So, which CBD brands are best for pain relief? We compared the prices, manufacturing process, third-party testing, product variety, formulas, and other criteria. Below are our top picks.

Compare top CBD oil products for pain relief:

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Receptra Naturals
Receptra Naturals
Green Roads
Green Roads
Charlotte's Web
Charlotte's Web
CBDMedic
CBDMedic
CBDfx
CBDfx
PlusCBD Oil
PlusCBD Oil
Lazarus Naturals
Lazarus Naturals
CBDistillery
CBDistillery
cbdMD
cbdMD
Endoca
Endoca
fourfivecbd
fourfivecbd
Our Score
8.8 /10Read Review
8.5 /10Read Review
8.6 /10Read Review
8.6 /10Read Review
9.4 /10Read Review
8.8 /10Read Review
8.6 /10Read Review
7.5 /10Read Review
CBD ConcentrationUp to 15 mg100 mg - 3500 mg240 mg - 1800 mg50 mg - 200 mg15 mg - 600 mg50 mg - 1500 mg200 mg - 6000 mg500 mg - 5000 mg100 mg - 7500 mg300 mg - 3000 mg250 mg - 2000 mg
Price Range$5.95 - $249.95$4.99 - $420$34.99 - $274.99$19.99 - $39.99$6.99 - $174.99$11.95 - $145.95$12 - $2400$35 - $240$9.99 - $339.99$15 - $286$37.4 - $143.54
Price Per Mg CBD$0.06 - $0.11$0.06 - $1.2$0.07 - $1$0.1 - $0.2$0.09 - $0.21$0.06 - $0.2$0.03 - $0.06$0.07 - $0.04$0.04 - $0.1$0.1 - $0.8$0.08 - $0.15
THC Concentration< 0.3%< 0.3%< 0.3%< %< 0.3%< 0.3%< 0.3%< 0.30%< 0.3%< 0.3%< 0.2%
VisitVisit SiteVisit SiteVisit SiteVisit SiteVisit SiteVisit SiteVisit SiteVisit SiteVisit SiteVisit SiteVisit Site
8Out of 10
Read Review
CBD Amount Range
Up to 15 mg
Price Range
$5.95 - $249.95
Visit Site
May Support
N/A
Consumption Method
Oil & Tinctures, Creams & Topicals, Capsules, Pets - Tinctures
Extract Types
Full Spectrum, Broad Spectrum
CBD Strength
Up to 15 mg, Oils & Tincturs: 16.6 - 66.6 mg/ml, Creams & Topicals: 10.6-11.4 mg/ml, Pets: 16.6 mg/ml
Price Per Mg CBD
$0.06 - $0.11
THC Concentration
< 0.3%
Offers Tastes
Yes
Third Party Lab Results
Yes
Additional Information
Non-GMO, Organic, Pesticide Free, Kosher, Vegan, Gluten Free, Ethanol
Hemp Source
Colorado Grown in Cañon City, CO
Customer Service By
Email, Facebook
CBD Extract Method
Ethanol
Free Sheeping
No
Worldwide Shipping
USA
Money Back Guarantee
Yes
Military Veteran Discount
Yes
Samples
No

15% Off - site width
Expires On: Unlimited

Receptra is an excellent choice for CBD-based relief because it offers both oil and topical products, different CBD potencies to suit varying levels of physical discomfort, and includes other ingredients that may help alleviate pain, such as turmeric, all at a reasonable price.

Established in 2016, Colorado’s Receptra is a CBD brand catering to athletes and other active individuals. The company offers full-spectrum CBD oils and topicals with various potencies and different formulas, including pet products and THC-free options.

Receptra works together with local Colorado farmers who cultivate organic, non-GMO hemp. The company also uses independent laboratories to provide extensive third-party reports of their products, including potency, heavy metals, microbials, residual solvents, and foreign matter. The results of these tests can be viewed online by entering your product code.

There’s good reason Receptra is our top pick. For starters, it focuses only on CBD oil and topical products: two forms of CBD best suited for helping with inflammation and other types of physical discomfort.

Better yet, the company offers products with low, medium, and high CBD potencies so that everyone can find relief for their discomfort, regardless of severity.

Another notable feature of Receptra’s products is that many of them include additional ingredients that may help with physical discomfort, such as turmeric. This herb has long been used for its anti-inflammatory effects, and there is some research evidence that it may help with arthritis and other conditions linked to inflammation.

Here’s a quick rundown on Receptra’s lineup:

  • Standard CBD oil: potency of 25 or 50 mg CBD per ml. Available in 15, 30, and 60 ml sizes. Contains full-spectrum hemp extract, MCT and sunflower carrier oils, and mint/berry flavoring.
  • CBD oil with turmeric: potency of 17, 33, or 67 mg CBD per ml. Available in 15, 30, and 60 ml sizes. Contains full-spectrum hemp extract, a mixture of standard carrier oils, mint/berry flavoring, and the anti-inflammatory ingredient turmeric. Also has a THC-free option.
  • Topical CBD cream: potency of 11 mg CBD per gram. Available in 1.25 and 2.5 oz sizes. Contains full hemp extract, and other ingredients with potential pain-relieving properties: camphor, arnica, jojoba, jasmine, and ylang-ylang oils. Also has a THC-free option.
  • Low-potency CBD body butter and lip balm
  • Pet CBD oil

Receptra also offers several product bundles with discount prices. The company’s products cost $5.95–$249.95, which works out to about $0.09 per mg of CBD — just around the market average.

Pros: Cons:
  • Multiple CBD potencies for varying levels of physical discomfort
  • Additional ingredients that may be helpful, such as turmeric
  • Affordable prices ($0.09 per mg of CBD)
  • Extensive third-party potency test results available online
  • Offers CBD topicals, which work great for localized relief
  • Lack of vape products: the ideal form of CBD for rapid relief
  • Lack of detailed information about the company
  • Product labels do a poor job of demonstrating THC levels and other useful info
  • Only one topical CBD potency

Watch our Endoca video review:

 

Editor’s Pick – Green Roads

8.8Out of 10
Read Review
CBD Amount Range
100 mg - 3500 mg
Price Range
$4.99 - $420
Visit Site
May Support
N/A
Consumption Method
Oil & Tinctures, Creams & Topicals, Pets - Tinctures, Capsules, Gummies & Edibles, Other
Extract Types
Broad Spectrum
CBD Strength
100 mg - 3500 mg, Oils & Tinctures: 16.6-60.6mg/ml; Gummies & Edibles: 10-50mg per gummy; Creams & Topicals: 0.6-10mg/ml; Capsules: 25mg per capsule
Price Per Mg CBD
$0.06 - $1.2
THC Concentration
< 0.3%
Offers Tastes
Yes
Third Party Lab Results
Yes
Additional Information
Non-GMO, Organic, Pesticide Free, Vegan, Gluten Free, CO2
Hemp Source
NA
Customer Service By
Email, Facebook
CBD Extract Method
CO2
Free Sheeping
No
Worldwide Shipping
United States, American Samoa, District of Colombia, Federated States of Micronesia, Guam, Marshall Islands, Northern Mariana Islands, Palau, Puerto Rico, Virgin Islands
Money Back Guarantee
Yes
Military Veteran Discount
Yes
Samples
NA

Free Shipping with orders over $50
Expires On: Unlimited

A CBD brand known for transparency and quality, Green Roads offers many products that can be used for relieving physical discomfort, including CBD oil, capsules, edibles, and topicals.

The Florida-based company was established in 2012, quickly growing into the largest privately-owned CBD business in the U.S. Green Roads is so popular that its products have thousands of satisfied customer reviews.

The company’s success is not surprising: the company doesn’t cut any corners. Its products are made from organic, non-GMO hemp grown in Colorado and backed by extensive third-party test reports. Better yet, they come in a variety of potencies and flavors.

Green Roads also provides clear information about its founders — one of whom is a licensed pharmacist — showing that it has nothing to hide, unlike many anonymous CBD brands.

The company uses broad-spectrum CBD extract for all products, which means they contain zero THC. This makes it a good option for athletes and people who have to have to pass employment drug tests.

Green Roads is a solid choice for relieving physical discomfort thanks to its wide variety of CBD product types and potencies:

  • CBD oil: potency of 7 to 58 mg CBD per ml. Available in 15, 30, and 60 ml sizes. Contains broad-spectrum hemp extract, vegetable glycerin, sunflower lecithin, hemp seed oil, and mint/berry flavoring.
  • CBD topicals: A skincare cream and two products the company claims help with muscle and joint pain: a roll-on and a cream with 100-500 mg CBD and additional pain-relieving ingredients such as capsicum and menthol.
  • CBD terpenes: Broad-spectrum oil with a potency of 6.7 mg CBD/ml mixed with a specific blend of cannabis terpenes. Available in a single-dose, 1 ml syringe or 15 ml bottle.
  • CBD capsules: 30 vegetarian-friendly capsules containing 25 mg of broad-spectrum hemp extract with the same ingredients as the CBD oil.
  • CBD gummies: delicious gummy bears, fruit bites, and froggies with 20, 25, or 50 mg of CBD. Available in different flavors, formulations, and counts.
  • CBD-infused tea and coffee
  • CBD sleep syrup

Green Roads also offers several product bundles. Its products range in price from $5 to $342.50, and cost $0.16 per mg of CBD, although a few products can cost as much as $0.86.

Pros: Cons:
  • Topicals claimed to be designed specifically for pain relief
  • Free shipping with purchase of over $100
  • Wide variety of product categories and CBD concentrations
  • 50% discount for military and first responders
  • Extensive, easy-to-access third-party testing for all products
  • Not as cheap as some other popular brands ($0.16 per mg CBD)
  • Lack of detailed information about manufacturing and extraction
  • No full-spectrum products, which are slightly more effective
  • Lack of vape products: the ideal form of CBD for rapid relief

Watch our interview with Green Roads CBD:

 

Editor’s Pick – Charlotte’s Web

8.5Out of 10
Read Review
CBD Amount Range
240 mg - 1800 mg
Price Range
$34.99 - $274.99
Visit Site
May Support
Sleep
Consumption Method
Oil & Tinctures, Creams & Topicals, Gummies & Edibles, Capsules, Pets - Tinctures, Pets - Edibles, Other
Extract Types
Isolate, Full Spectrum, Broad Spectrum
CBD Strength
240 mg - 1800 mg, Oil & Tinctures: 7-60mg/ml; Capsules:15-25mg per capsule; Creams & Topicals: 10-10.56mg/ml; Gummies & Edibles: 10 mg per gummy
Price Per Mg CBD
$0.07 - $1
THC Concentration
< 0.3%
Offers Tastes
Yes
Third Party Lab Results
Yes
Additional Information
Non-GMO, Organic, Pesticide Free, Kosher, Vegan, Gluten Free, Ethanol, CO2
Hemp Source
NA
Customer Service By
Email, Facebook
CBD Extract Method
Ethanol, CO2
Free Sheeping
No
Worldwide Shipping
No
Money Back Guarantee
No
Military Veteran Discount
Yes
Samples
false

10% Off - 10% Off Charlotte's Web Hemp When You Buy In Bulk
Expires On: Unlimited

One of the most recognizable and trusted names in CBD, Charlotte’s Web offers several high-quality products that may help with physical relief.

The company was founded by the Stanley Brothers, who created a special strain of cannabis with low THC and high CBD levels they called Charlotte’s Web in 2011.

This cultivar got its name from Charlotte, a girl who found relief from severe seizures by using the unique cannabis strain. The brothers modified the strain into one made from hemp, creating their CBD company in the process.

Charlotte’s Web is very particular about its hemp plants. It sources hemp from non-GMO, organic farms in Colorado, Oregon, and Kentucky. The company tests the soil, water, and the plants themselves during the growing process to make sure there’s no contamination and to maintain a specific cannabinoid and terpene composition.

Charlotte’s Web also utilizes extensive third-party testing accessible with product batch numbers and has a 98.9% rating under Good Manufacturing Practices (cGMP) standards. Better yet, it’s one of the only companies certified by the U.S. Hemp Authority, which highlights stringent product standards.

Thanks to its use of full-spectrum formulas and multiple CBD potencies, Charlotte’s Web offers many products that may be helpful for physical discomfort:

  • CBD oil: potency of 7 to 60 mg CBD per ml. Available in 30 and 100 ml sizes. Contains full-spectrum hemp extract, extra virgin olive oil or MCT oil as carrier oils. Comes in multiple flavors. Also has a THC-free option.
  • CBD capsules: vegetarian-friendly capsules with 15 or 25 mg of full-spectrum CBD mixed with virgin olive oil. Come in 30, 60, or 90-count containers.
  • CBD gummies: three types of tasty gummies containing 5 mg of full-spectrum CBD with 60 pieces per container. Charlotte’s Web claims its recovery gummies may be particularly helpful for physical discomfort thanks to containing additional anti-inflammatory ingredients.
  • A CBD cream and balm designed for skincare
  • CBD pet products

The company also sells several product bundles and bulk packs. Charlotte’s Web products range in price from $14.99 to $327.17.

This translates to $0.12 per mg of CBD, which is on the upper end of the average market price.

Pros: Cons:
  • U.S. Hemp Authority-certified
  • Third-party tested
  • Multiple product bundles that help you save money
  • High-quality hemp
  • Multiple CBD potencies for varying levels of discomfort
  • No USDA organic certification
  • Can be somewhat pricey for some products ($0.12 per mg CBD)
  • Third-party results not available unless you purchase products
  • Lack of vape products: the ideal form of CBD for rapid relief

 

Best Cream – CBD Medic Active Sports Pain Relief Ointment

8Out of 10
Read Review
CBD Amount Range
50 mg - 200 mg
Price Range
$19.99 - $39.99
Visit Site
May Support
N/A
Consumption Method
Creams & Topicals
Extract Types
Broad Spectrum
CBD Strength
50 mg - 200 mg, Creams & Topicals: 1-5 mg/ml
Price Per Mg CBD
$0.1 - $0.2
THC Concentration
< %
Offers Tastes
No
Third Party Lab Results
Yes
Additional Information
Organic,
Hemp Source
Colorado and Oregon
Customer Service By
Email
CBD Extract Method
N/A
Free Sheeping
No
Worldwide Shipping
US, UK, Germany, France, Spain, Australia, New Zealand, Brazil, Colombia, Mexico, Peru, South Africa
Money Back Guarantee
No
Military Veteran Discount
No
Samples
No

CHECK OUT CBDMedic'S OFFERS
Expires On: Unlimited

CBD Medic’s pain relief ointment is our top pick for muscle and joint pain and soreness. This ointment has a sizable amount of menthol (10%) and camphor (15%), the two most popular ingredients for topical pain and inflammation relief.

The cool and warming sensations of these natural compounds soothe painful, sore, and tired muscles. Although CBD Medic recommends this product for working out, it can be used for any sort of muscle or joint discomfort.

The 40-gram ointment also contains broad-spectrum CBD (200 mg) and other natural ingredients such as beeswax, cottonseed oil, and other essential oils. The CBD in this third-party tested topical comes from quality hemp cultivated in Colorado and Oregon.

CBDMEDIC also offers stick and oil versions of its ointment, as well as similar products for back & neck and foot & ankle pain. All these products cost $0.20 per mg of CBD, which is considered around average.

Pros: Cons:
  • Effective pain-relieving formula
  • Multiple versions for different types of pain and product type
  • Whole-plant hemp product
  • All-natural ingredients
  • High-quality hemp source
  • Third-party tested
  • Reasonable price ($0.20 per mg)
  • Lacks third-party tests for pesticides and heavy metals
  • Relatively low CBD potency
  • Lack of detailed information about the company

Watch our video interview with CBD Medic:

 

Best Value – Lazarus Naturals

9.4Out of 10
Read Review
CBD Amount Range
200 mg - 6000 mg
Price Range
$12 - $2400
Visit Site
May Support
N/A
Consumption Method
Oil & Tinctures, Creams & Topicals, Isolate, Capsules, Pets - Tinctures, Other
Extract Types
Full Spectrum, Isolate
CBD Strength
200 mg - 6000 mg, Oils & Tinctures 15-50mg/ml; Capsules: 10-50mg per capsule; Creams & Topicals: 3.3-20mg/ml
Price Per Mg CBD
$0.03 - $0.06
THC Concentration
< 0.3%
Offers Tastes
Yes
Third Party Lab Results
Yes
Additional Information
Non-GMO, Organic, Pesticide Free, Vegan, Gluten Free, Ethanol
Hemp Source
Oregon
Customer Service By
Email
CBD Extract Method
Ethanol
Free Sheeping
No
Worldwide Shipping
USA
Money Back Guarantee
No
Military Veteran Discount
Yes
Samples
No

Save 15% Off Your Next Order at Lazarus Naturals (Site-Wide)
Expires On: Unlimited

When it comes to value, Lazarus Naturals is arguably the best choice for CBD. On average, every mg of CBD from Lazarus costs only 4 cents: far below what most companies charge.

One of the most reputable CBD companies in the United States, Lazarus Naturals was founded in 2014. Lazarus is spoken well of by customers and industry insiders alike for its incredibly low prices, quality products, and company ethics.

Lazarus Naturals stands out from the competition in several ways. For starters, its products are third-party tested, and the testing results are easily accessible on each product page.

More importantly, most of the company’s hemp (70%) is sourced from Lazarus’ own Oregon farm. Furthermore, the company is entirely owned by its employees, which goes a long way towards explaining its affordable, high-quality products.

Lazarus also gives a massive 60% discount to veterans, people with disabilities, and low-income families. It’s quite apparent that the company cares about helping people rather than maximizing profits.

Lazarus’ product lineup has much to offer for physical discomfort. For one, most of the products are made with full-spectrum hemp extract, which contains all of the beneficial active ingredients in hemp. These compounds work together in a synergy known as the entourage effect, which means full-spectrum products may be more potent than pure CBD.

Here’s the complete rundown of the company’s products:

  • CBD oil: potency of 15 or 50 mg CBD per ml. Available in 15, 60, and 120 ml sizes. Contains full-spectrum hemp extract and MCT carrier oil. Comes in multiple flavors. Also has THC-free options.
  • CBD capsules: vegan capsules and gelatin softgels with the same ingredients as the full-spectrum CBD oil. Come in 10, 25, 50, and 100 mg potencies with 4 to 200 capsules per bottle. Also available in THC-free options with specialized ingredients.
  • CBD balms: full-spectrum topicals with 20 mg CBD per gram. Available in 0.5 oz and 2 oz sizes. Comes in unscented, Cedar Citrus, Lavender, Soothing Mint, and Portland Rose scents.
  • CBD massage oil: potency of 3.4 mg CBD per ml or 50 mg per tablespoon. Contains full-spectrum hemp extract mixed with other oils. Comes in 2, 8, and 16 oz volumes. This may be a particularly useful option for topical relief.
  • CBD coconut oil: contains 50 mg of full-spectrum CBD per teaspoon. Available in 1 oz and 4 oz sizes with a total of 300 or 1200 mg CBD.
  • CBD isolate: >99% pure CBD isolate powder. Available in 20 and 50-gram containers. Also comes in a terpene-infused variety with terpenes from specific cannabis strains, which add flavor and enhance beneficial effects.
  • RSO CBD oil: a high-potency CBD version of Rick Simpson Oil (RSO). Contains 100 mg of full-spectrum CBD per ml. Comes in 10 and 50 ml syringes.
  • Pet CBD oil tinctures

The company also offers several bundles with reduced prices. Lazarus Naturals’ products cost $6 to $450 and cost an unheard of $0.04 per mg of CBD. You simply won’t find this kind of value and quality elsewhere.

Pros: Cons:
  • One of the lowest CBD costs on the market ($0.04 per mg CBD)
  • Detailed third-party test results available online
  • Employee-owned company with 70% of hemp sourced from its own farm
  • Ethical, reputable, transparent company with excellent customer service
  • Free 3-day shipping on U.S. orders
  • No USDA organic certification
  • Lack of vape products: the ideal form of CBD for rapid relief

 

Best Value – CBDistillery

8.8Out of 10
Read Review
CBD Amount Range
500 mg - 5000 mg
Price Range
$35 - $240
Visit Site
May Support
N/A
Consumption Method
Oil & Tinctures, Capsules, Creams & Topicals, Vapes & Liquids, Pets - Tinctures, Isolate
Extract Types
Full Spectrum, Isolate
CBD Strength
500 mg - 5000 mg, Oils & Tinctures: 5-166 mg/ml, Gummies & Edibles: 30 mg per gummy, Capsules: 25-30 mg per capsule, Creams & Topicals: 5.5 - 16.6 mg/ml, Vapes & Liquides: 200 mg
Price Per Mg CBD
$0.07 - $0.04
THC Concentration
< 0.30%
Offers Tastes
Yes
Third Party Lab Results
Yes
Additional Information
Non-GMO, Pesticide Free, Gluten Free, CO2
Hemp Source
United States
Customer Service By
Live Chat, Email, Facebook
CBD Extract Method
CO2
Free Sheeping
No
Worldwide Shipping
USA
Money Back Guarantee
Yes
Military Veteran Discount
Yes
Samples
No

The CBDistillery Deal: Get 15% Off Your First Order With Email Sign Up at The CBDistillery
Expires On: Unlimited

CBDistillery is another top-notch CBD company known for its low prices ($0.06 per mg CBD) and exceptional quality. It has a variety of products that can help with physical discomfort, including CBD oil, softgels, creams, and vape products.

Founded in 2016, Colorado’s CBDistillery is one of the best known CBD brands in the U.S. Thanks to its affordable pricing, transparency, and superb products, the company has received thousands of overwhelmingly positive reviews.

CBDistillery checks off all the marks of a quality CBD business: organic, non-GMO Colorado hemp source; carbon dioxide (CO2) and ethanol extraction, the two leading ways to extract CBD; and extensive third-party testing available on its website.

Another notable feature of CBDistillery is its incredibly helpful product labels, which clearly state useful information such as CBD and THC content, ingredients, and recommended dosage. The company is also one of the few to be certified by the U.S. Hemp Authority, which highlights excellent quality standards.

CBDistillery offers multiple products that may help with physical discomfort, including CBD oils, capsules, gummies, isolates, topicals, and even disposable vape pens in a variety of CBD potencies.

Here are the highlights of the company’s lineup:

  • CBD oil: potency ranging from 8 to 167 mg CBD per ml. Available in 30 ml bottles. Contains full-spectrum hemp extract and MCT carrier oil. Comes in multiple flavors. Also available in THC-free options.
  • CBD capsules: softgels or vegan capsules with the same ingredients as the CBD oil. Comes in 25 and 30 mg potencies in 30 or 60-count bottles. Also available in THC-free options.
  • CBD topicals: CBD salve, cream, lip balm, and roll-on stick. CBDistillery claims the salve is formulated to provide relief after tough workouts and long days and contains 500 mg of full-spectrum CBD in a 1 oz container, while the stick combines 500 mg of CBD with menthol, the most popular pain-relieving topical ingredient.
  • CBD gummies: tasty edible treats containing 25 mg CBD isolate with 30 pieces per container. Come in regular and sleep-focused formulations.
  • CBD isolate: >99% pure CBD isolate powder. Available in a 1, 10, and 100-gram containers.
  • CBD vape e-liquid: potency of 17 or 33 mg CBD per ml in 30 ml bottles. Contains broad-spectrum CBD mixed with VG/PG and comes in multiple flavors. Pre-filled, disposable CBD vape pens and cartridges are also available.
  • CBD oil for pets

The company also sells several product bundles at a reduced price. CBDistillery’s products are priced anywhere from $6 to $2000. This is equivalent to $0.06 per mg of CBD: an incredibly low cost when we consider the company’s quality.

Pros: Cons:
  • Wide variety of products with multiple potencies
  • High-quality hemp and extraction process
  • Excellent value ($0.06 per mg CBD)
  • Third-party testing and easily accessible test reports
  • U.S. Hemp Authority-certified
  • Lacks USDA organic hemp certification
  • No third-party tests for heavy metals

Watch our video review of CBDistillery

 

Best Potency – cbdMD

8.6Out of 10
Read Review
CBD Amount Range
100 mg - 7500 mg
Price Range
$9.99 - $339.99
Visit Site
May Support
N/A
Consumption Method
Oil & Tinctures, Vapes & Liquids, Gummies & Edibles, Creams & Topicals, Gummies & Edibles, Capsules, Pets - Tinctures, Pets - Edibles, Other
Extract Types
Broad Spectrum
CBD Strength
100 mg - 7500 mg, Oils & Tinctures: 10-250mg/ml; Gummies & Edibles :10-25mg per gummy; Creams & Topicals:3.3-30mg/ml; Capsules:15-50mg per capsule; Pets: 5-100mg/ml
Price Per Mg CBD
$0.04 - $0.1
THC Concentration
< 0.3%
Offers Tastes
Yes
Third Party Lab Results
Yes
Additional Information
Non-GMO, Vegan, Gluten Free, CO2
Hemp Source
Kentucky, Colorado
Customer Service By
Live Chat, Email, Facebook
CBD Extract Method
CO2
Free Sheeping
No
Worldwide Shipping
USA
Money Back Guarantee
Yes
Military Veteran Discount
No
Samples
No

15% off - Only for Leafreport Users! Save 15% Off Your Order at cbdMD (Site-Wide)
Expires On: Unlimited

If you’re looking for potent CBD products to deal with significant issues, cbdMD is one of the best options. This brand offers some of the highest CBD concentrations not only for CBD oil but many other product types.

CbdMD is a popular brand known for offering THC-free CBD products at competitive prices. The company uses only organic, non-GMO, American-grown hemp, and provides third-party lab test reports on its website.

CbdMD offers CBD oils, capsules, edibles, topicals, and pet products in multiple potencies, ensuring that everyone has a product that meets their unique dosage requirements.

In particular, the company is known for having some of the most potent CBD products on the market, which is great for people looking for high doses of CBD.

Here’s a detailed breakdown of cbdMD’s products:

  • CBD oil: potency ranging from 10 to 250 mg CBD per ml. The higher strength options are a particularly excellent choice for people who need significant relief. Available in 30 and 60 ml bottles. Contains broad-spectrum hemp extract and MCT carrier oil. Comes in multiple flavors.
  • CBD capsules: vegan capsules with the same ingredients as the CBD oil. Come in potencies ranging from 15 mg to 50 mg in 30 or 60-count bottles.
  • CBD topicals: CBD lotion, anti-inflammatory cream, and pain relief roll-on. CbdMD claims the cream is formulated to relieve inflammation and contains 150–350 mg CBD per oz in addition to arnica and MSM, two ingredients with anti-inflammatory and pain-relieving properties. Meanwhile, cbdMD says the roll-on is designed to relieve pain and contains 100–500 mg CBD per oz mixed with menthol, a common pain-relieving ingredient.
  • CBD gummies: delicious gummies containing 10 or 25 mg CBD with 30 pieces per container.
  • CBD bath bombs: with a potency of 100 mg CBD each and additional relaxation-promoting ingredients such as eucalyptus, this unique product may be potent enough to provide relief and relaxation. Comes in multiple scents.
  • CBD pet products

CbdMD’s products are priced between $19.99 and $339.99 and the company also offers CBD bundles with reduced prices. With a cost of $0.11 per mg of CBD ($0.07 for tinctures), it’s one of the more affordable brands on the market.

Pros: Cons:
  • High CBD potency options
  • Great prices ($0.11 per mg CBD, $0.07 for oils)
  • Third-party testing and easily accessible test reports
  • Free shipping on all American orders
  • Lack of detailed information about the manufacturing process
  • No third-party tests for heavy metals and some other contaminants
  • Lack of vape products: the ideal form of CBD for rapid relief
  • No full-spectrum products, which are slightly more effective

 

Best Potency – Endoca

9Out of 10
Read Review
CBD Amount Range
300 mg - 3000 mg
Price Range
$15 - $286
Visit Site
May Support
Pain, Anxiety, Headaches, Inflammation, Seizures, Joint Support, Skin Care
Consumption Method
Oil & Tinctures, Creams & Topicals, Capsules, Isolate, Pets - Tinctures, Other
Extract Types
Full Spectrum, Isolate
CBD Strength
300 mg - 3000 mg, Oils & Tinctures: 30-150 mg/ml, Capsules: 10-50mg per capsule, Creams & Topicals: 25-150mg/ml, Pets: 30-150 mg/ml
Price Per Mg CBD
$0.1 - $0.8
THC Concentration
< 0.3%
Offers Tastes
No
Third Party Lab Results
Yes
Additional Information
Non-GMO, Organic, Pesticide Free, Kosher, Vegan, Gluten Free, CO2
Hemp Source
Cannabis sativa L
Customer Service By
Live Chat, Email, Facebook
CBD Extract Method
CO2
Free Sheeping
No
Worldwide Shipping
USA
Money Back Guarantee
Yes
Military Veteran Discount
Yes
Samples
No

20% off everything
Expires On: Dec 21, 2019

With high-strength options for CBD oil, capsules, topicals, and other products, Europe’s Endoca is a superb choice for people in need of potent CBD preparations.

The company was founded by Danish biochemist Henry Vincenty in 2008, who became committed to spreading the health benefits of hemp after seeing the ineffectiveness of pharmaceutical medicine.

Where Endoca truly stands out is its rigorous, scientific approach, going to great lengths to ensure exceptional CBD products.

For starters, Endoca tests its hemp seeds, growing plants, and the resulting hemp extracts to make sure they maintain a high standard of quality and safety.

Also, Endoca makes extensive use of third-party testing, including tests for the terpene profile of their CBD extracts. The company makes all of these test reports easily accessible on their website.

Endoca uses organic, non-GMO hemp grown in Scandinavia, an excellent climate for cultivating the plant, and utilizes supercritical CO2 extraction, the most advanced method of extracting CBD and other beneficial hemp compounds.

Another unique characteristic of Endoca is that the company offers multiple “raw” hemp CBD products. These products undergo minimal processing and contain high levels of CBDA, CBD’s parent molecule which has similar health benefits.

Endoca offers a wide range of high-quality CBD oils, creams, capsules, concentrates, pet formulations, isolates, edibles, and more. Most of the company’s products are made with full-spectrum hemp extract and come with high-strength options, making them ideal for those in need of high-strength CBD.

Here’s a closer look at Endoca’s product lineup:

  • CBD oil: potency of 30 (medium) and 150 mg (high) CBD per ml. Available in 10 ml bottles. Contains full-spectrum hemp extract and hemp seed carrier oil. Also available in raw hemp variety.
  • CBD capsules: vegan capsules with the same ingredients as the CBD oil. Come in 10 and 50 mg potencies with 30 capsules per bottle. Also available in raw hemp variety.
  • CBD topicals: CBD lip balm, salve, and cream. The salve has a potency of 25 mg CBD per ml and comes in a 30 ml jar and Endoca claims it can be used to relieve pain. The cream has a potency of 3 or 15 mg CBD per ml in a 100 ml jar.
  • CBD extract: potent hemp oil concentrate containing 200 or 300 mg CBD per ml in a 10 ml syringe. This product is ideal for people who require very high CBD doses. Also available in raw hemp formula.
  • CBD crystals: 500 mg of >99% pure CBD isolate powder.
  • CBD chewing gum
  • CBD oil for pets
  • CBD suppositories

Endoca’s products range in price from €7 to €255 and include several CBD bundle packs. The cost per mg of CBD comes out to €0.11 (€0.09 for tinctures), which is quite reasonable for such superb quality.

Pros: Cons:
  • Large variety of high-quality products available in medium and high potencies
  • Detailed third-party test results available online
  • High-quality hemp and extraction process
  • Free shipping on European orders, and free after $74 for U.S. orders
  • Reasonable prices (€0.11 per mg CBD, €0.09 for tinctures)
  • Lacks USDA organic certification
  • More expensive than value brands such as Lazarus Naturals
  • Lack of vape products: the ideal form of CBD for rapid relief

Watch our Endoca video review:

 

Best Non-THC – CBDistillery

8.8Out of 10
Read Review
CBD Amount Range
500 mg - 5000 mg
Price Range
$35 - $240
Visit Site
May Support
N/A
Consumption Method
Oil & Tinctures, Capsules, Creams & Topicals, Vapes & Liquids, Pets - Tinctures, Isolate
Extract Types
Full Spectrum, Isolate
CBD Strength
500 mg - 5000 mg, Oils & Tinctures: 5-166 mg/ml, Gummies & Edibles: 30 mg per gummy, Capsules: 25-30 mg per capsule, Creams & Topicals: 5.5 - 16.6 mg/ml, Vapes & Liquides: 200 mg
Price Per Mg CBD
$0.07 - $0.04
THC Concentration
< 0.30%
Offers Tastes
Yes
Third Party Lab Results
Yes
Additional Information
Non-GMO, Pesticide Free, Gluten Free, CO2
Hemp Source
United States
Customer Service By
Live Chat, Email, Facebook
CBD Extract Method
CO2
Free Sheeping
No
Worldwide Shipping
USA
Money Back Guarantee
Yes
Military Veteran Discount
Yes
Samples
No

The CBDistillery Deal: Get 15% Off Your First Order With Email Sign Up at The CBDistillery
Expires On: Unlimited

Whether it’s due to being drug tested at work, extreme sensitivity to THC, or another reason, some people prefer to use formulations THC-free formulations.

In that case, CBDistillery is a good choice, highlighted by affordable prices, extensive third-party testing, and multiple potencies.

The company’s THC-free products include:

  • THC-free CBD oil: potency ranging from 8 to 167 mg CBD per ml. Available in 30 ml bottles. Contains CBD isolate and MCT carrier oil.
  • THC-free CBD capsules: softgels containing the same ingredients as the CBD oil. Potency of 30 mg with 30 or 60 capsules per bottle.
  • CBD isolate: >99% pure CBD isolate powder. Available in a 1, 10, and 100-gram containers.
  • CBD vape e-liquid: potency of 17 or 33 mg CBD per ml in 30 ml bottles. Contains broad-spectrum CBD mixed with VG/PG and comes in multiple flavors. Pre-filled, disposable CBD vape pens and cartridges with CBD isolate are also available.

You can verify that these products contain zero THC by checking the lab results right on the product page. CBDistillery’s THC-free range is priced anywhere from $19 to $2000. This translates to a low price of $0.02–$0.14 per mg of CBD.

Pros: Cons:
  • High-quality hemp and extraction process
  • Excellent value ($0.02–$0.14 per mg CBD)
  • Third-party testing and easily accessible test reports
  • U.S. Hemp Authority-certified
  • No USDA organic certification
  • No third-party tests for heavy metals
  • Lacks some THC-free product categories, such as vapes

 

Best Non-THC Fourfivecbd (UK only)

7.5Out of 10
Read Review
CBD Amount Range
250 mg - 2000 mg
Price Range
$37.4 - $143.54
Visit Site
May Support
N/A
Consumption Method
Capsules, Oil & Tinctures, Creams & Topicals
Extract Types
Broad Spectrum, Full Spectrum
CBD Strength
250 mg - 2000 mg, Oils & Timctures: 16.6-66.6mg/ml; Capsules: 10mg per capsule; Creams & Topicals: 6.6 mg/ml
Price Per Mg CBD
$0.08 - $0.15
THC Concentration
< 0.2%
Offers Tastes
Yes
Third Party Lab Results
Yes
Additional Information
Non-GMO, Organic, Pesticide Free, Vegan, Gluten Free, CO2
Hemp Source
Croatia, Slovenia, Czech Republic, Slovakia and the Netherlands
Customer Service By
Email, Facebook
CBD Extract Method
CO2
Free Sheeping
No
Worldwide Shipping
UK, Ireland
Money Back Guarantee
No
Military Veteran Discount
No
Samples
false

15% OFF - Get 15% off your purchase - only for Leafreport.com users!
Expires On: Unlimited

For UK residents in need of THC-free products, Fourfivecbd is a solid choice.

This CBD brand was founded by two British rugby players, Dom Day and George Kruis, who claim to have used CBD throughout their careers to help with injuries, pain, and overall recovery.

Although it’s not as well-known as some other companies on this list, Fourfivecbd has a lot of things going for it. For starters, the company uses European hemp cultivated in Croatia, Slovenia, Czech Republic, Slovakia, and the Netherlands. This hemp is then extracted using carbon dioxide (CO2), the gold standard of the CBD industry.

Fourfivecbd’s products also undergo extensive third-party testing to make sure they’re potent and safe, and the results can be viewed on the company’s website.

The company’s claims its products are particularly focused on helping athletes and other active individuals recover and stay in good health. As such, it’s not surprising that many of its products are free of THC, which is a banned substance under sport governing bodies.

Fourfivecbd’s products are even tested by the Banned Substance Control Group (BSCG) to make sure that they’re free of all compounds prohibited by the World Anti-Doping Agency (WADA) so that athletes taking them are not wrongfully penalized.

Fourfivecbd’s THC-free products include:

  • 0% THC CBD oil: potency of 33 mg CBD per ml in a 30 ml bottle. Contains CBD isolate and MCT carrier oil. Available in two flavors.
  • CBD balm: potency of 7 mg CBD per ml in a 45 ml container. The company claims this balm is designed to ease aches, pains, soreness, and inflammation. It also contains other pain-relieving ingredients such as menthol.
  • CBD muscle rub: same potency as the CBD balm and similar ingredients.

These products cost £34.99 to £74.99, or £0.07–£0.12 per mg of CBD. This price is about average for the UK CBD market.

Pros: Cons:
  • Reasonable prices (£0.07–£0.12 per mg CBD)
  • Comprehensive third-party testing and easily accessible test results
  • Products claimed to be designed for relieving aches and pains
  • High-quality extraction process
  • Limited product lineup
  • Few CBD potency options
  • Slow customer support
  • Lack of detailed information about the company and its manufacturing process

 

 

Can CBD Oil Help Relieve Pain?

Table of contents:

 

CBD is the acronym for cannabidiol, one of the 108 (at least) phytocannabinoids found in members of the cannabis plant. CBD has several different evidence based effects including anti-nausea, as an anticonvulsant, an anti-anxiety agent, anti-inflammatory agent, an immune modulator and an antioxidant. Importantly, CBD has also been shown to be an effective pain reliever. [1]

It is important to know that the effects of CBD are significantly different than those of THC, another cannabinoid with a similar chemical structure, but with different actions. One of the most important differences is that CBD is not an intoxicant and won’t get you high while THC is intoxicating. As an aside, most times you will hear or read that CBD is not a “psychoactive” agent. While this is true in the way most people think of psychoactive agents, CBD does have anti-anxiety and antidepressant effects and it does affect mood, so the more correct technical term is non-intoxicating).[2]

To understand how CBD relieves pain, let’s start first with the human endocannabinoid system: the ancient regulatory system on which the cannabinoids act.

The Endocannabinoid System

Cannabis is one of the oldest medicinal plants known to humans and the endocannabinoid system is an ancient, evolutionarily conserved system that plays a key role in homeostasis, the process that helps balance the body’s metabolic, immune and hormonal systems. The endocannabinoid system (ECS) plays vital roles in regulation of the stress response, mood, memory, reward systems that control appetite, libido, addictions and metabolic processes like the regulation of blood sugar levels and the balance of energy in the body. The fact that such a wide variety of systems can be regulated by the ECS gives us a clue as to how important it is.

Endocannabinoids are the signaling molecules for the ECS. Structurally, they don’t “look” like cannabinoids, which are phytocannabinoids but the endocannabinoids interact with receptors of the ECS in a way similar to a lock (the receptors) and key (the endocannabinoids or phytocannabinoids) The two main endocannabinoids found in humans are anandamide (AEA) and 2-arachidonoylglycerol (2-AG). These substances (the keys) bind to one of two receptors (the locks), either CB1 or CB2.

  • AEA binds weakly to both the CB1 and CB2 receptors
  • 2-AG binds strongly to both the CB1 and CB2 receptors

 

CB1 and CB2 Receptors

CB1 and CB2 receptors are found in different areas of the body. CB1 is found mostly in the brain, the spinal cord and on the nerves that run through the body. One current theory is that slight genetic changes in the CB1 receptor may help explain some mood disorders like depression and anxiety.[3]

CB2 receptors are found on cells of the immune, reproductive, digestive, cardiovascular and musculoskeletal systems.

THC, the intoxicating or psychoactive cannabinoid binds more strongly to CB1. CBD has a different profile;t binds weakly to both CB1 and CB2 receptors. More recent research indicates that THC can affect additional receptors (beyond the CB1 and CB2 receptors) in different ways that can result in various health benefits. Some of these different ways include:

  • CBD may bind to serotonin receptors – This may help explain the anti-anxiety effect of CBD. This may also help explain other effects including alterations in pain perception and delivery of pain relief. [4]
  • CBD also binds to a type of receptor known as transient receptor potential channels, of the vanilloid subtype usually abbreviated as TRPVs. The TRPVs act as “sensors” for pain, heat and pressure. [5] CBD binds to TRPV1. This receptor is specifically involved in the perception of pain. The endocannabinoid AEA also binds to the TRPV1 receptor as does the substance capsaicin derived from hot chili peppers. Capsaicin is used in several topical agents designed to decrease pain.
  • CBD may also act as a natural Selective Serotonin Reuptake Inhibitor (SSRI). The SSRI’s are a class of drug used to treat anxiety and depression.[6]
      • In addition to acting as an SSRI, CBD may also inhibit the reuptake of AEA. The end result is that AEA hangs around longer and exerts a greater effect.

Overall, the evidence is building that CBD acts as a – get ready for it—an indirect antagonist of cannabinoid agonists. Translation: CBD acts on parts of a number of different receptors to balance out the actions of other cannabinoids like THC. [7]

Human CBD receptors chart

 

What Is Pain?

Pain is a subjective response to a sensory stimulus. That stimulus could be heat, pressure or some form of injury. Pain is difficult to measure because it is subjective. It all depends on who is experiencing the pain. We’ve all known people who seem to wince at the smallest pain while others seem to have a great deal of tolerance to pain.

Medically, two main types of pain are recognized:

  • Nociceptive: pain that comes from damaged tissues
  • Neuropathic: pain that comes from damaged nerves

There is also a third major form of pain recognized by many physicians and researchers. This is the pain that comes from some form of neurologic dysfunction that is not necessarily accompanied by any signs of damage. Fibromyalgia is a good example of this form of pain.

Some researchers, on the other hand, classify pain as nociceptive, neuropathic, inflammatory or due to cancer.

There are other ways to describe pain. It can be acute or chronic, but it can also be described as sharp, dull, achy, pressure, stabbing or in a number of other ways. Again, it is often how the person going through the pain perceives it.

Acute pain is sudden pain that usually signals an injury or sudden damage to tissues. It is meant to immediately notify you that you are in danger! Acute pain is carried by fast-acting “A” type nerve fibers. Chronic pain is pain that lasts longer and it is carried by the slower “C” fibers. The sections of the nervous system that perceive pain evolved to protect us from movement that might make the pain or injury worse. It also seems to encourage us to take it easy, to rest and recover from the injury.

 

How Does CBD Reduce Pain?

The quick answer is we don’t really know. We are in the early stages of CBD research. This is often difficult research to perform. Why? There are many technical, legal and cultural reasons, but the most complicated reasons may be technical. We are in possession of lots more information then we had, say 5 years ago, and more are being published all the time.

Here is some of the information we have now:

The current understanding of the actions of CBD in the context of pain relief is that “cannabinoids, both plant derived and endogenous, act simultaneously on multiple pain targets.”[10] That is part of the reason CBD research is complicated. It looks like CBD can act on multiple receptors and multiple targets at the same time.

 

Evidence Based Use of CBD for Chronic Pain Relief

While it is clear that much more research needs to be done, currently there is enough evidence to support at least a trial of CBD in several different pain related conditions including: [10], [13],[14],[15]

  • Chronic non-cancer pain
  • Neuropathic pain
  • Abdominal pain
  • Rheumatic and joint pain
  • Chronic cancer pain
  • Neurological pain

Not all the studies looked specifically at CBD. That is another area that needs to be expanded. Several studies examined medical cannabis and synthetic cannabinoids.

The side effects associated with CBD use tend to be mild, short-term, well tolerated and are often related to other uses of CBD;eg. drowsiness, fatigue, changes in appetite and diarrhea.

Overall, CBD research is in its infancy, but it is reasonable to expect that every year there will be a better understanding of how CBD may function to decrease pain levels. Currently, there is sufficient evidence and CBD has a good enough safety profile so that it is definitely worth of trial for most people suffering from chronic pain. It is recommended that you work with a knowledgeable healthcare professional when using CBD.

 

Evidence Based Use of CBD for Arthritis Pain Relief

Arthritis is common.- In fact, the term arthritis covers over 100 different conditions that all possess the common element of joint pain. Arthritis can take the form of:

  • Degenerative arthritis is the most common type of arthritis and due, at least in part, to “wear and tear” of joints. During a lifetime, the cartilage of the joints accumulates damage, eventually often resulting in swelling, inflammation, stiffness and pain.
  • Inflammatory arthritis is a somewhat redundant terminology because arthritis IS an inflammatory process. This is a class designation and includes rheumatoid arthritis (RA), psoriatic arthritis and other autoimmune processes like ankylosing spondylitis and lupus. Gout and Lyme disease can also produce arthritic syndromes. Gout and pseudogout are sometimes considered metabolic forms of arthritis.
  • Infectious arthritis is caused by bacterial, viral or fungal infections that affect the joints. Bacterial infections may be due to Salmonella, Shigela, Chlamydia and Neisseria species. Hepatitis C can also cause infectious arthritis.

At this point, you won’t find it too surprising that there have not been many clinical studies using just hemp derived CBD for pain relief, either oral or topical, while managing the various forms of arthritis. However, some case studies were recently published [16] using CBD in various forms. One case involved a 50 year old woman with multiple autoimmune conditions including rheumatoid arthritis who was successfully assisted using 600mg CBD of isolate in MCT oil given by the sublingual (under the tongue) route. The doses were divided and given 3 times a day (200 mg each) and the woman reported significant improvement in her pain levels, quality of life, emotional well being and physical ability to function normally.

In a recent review cleverly titled “Joints for Joints”, one of the Key Points stated that “ CBD is effective in reducing inflammation and pain and might enhance the efficacy of therapeutic drugs. “[17] This finding suggests that oral CBD might reduce pain by reducing inflammation- and that it might be best used in conjunction with current medications. That is a conversation that you would need to have with your physician.

Topically, CBD has been anecdotally widely reported to reduce pain. Topical applications have the advantage of working directly on a painful joint and avoid first pass metabolism. There are no current recommendations regarding the quantity to use.-A reasonable rule of thumb is to fully cover the painful area with as small amount of topical CBD as possible and to repeat the process every 2-4 hours as needed. The temptation is often to go for the most “potent” topical CBD but, depending on the area and the degree of pain, it is often reasonable and cost-effective to start with a low dose and increase as needed.

Other studies have used synthetic cannabinoids or combinations of CBD and THC which make interpretation difficult- but it can be concluded from these studies that CBD alone is worth a try if you have any form of arthritis. A reasonable recommendation would be to start with a topical form of CBD if your arthritis is limited to one, two or three joints. If more joints are involved, oral CBD may represent a better approach. There will be some trial and error involved in finding your dose so be patient.

 

Evidence Based Use of CBD for Multiple Sclerosis

Most of the studies done on cannabinoids and multiple sclerosis (MS) have used Sativex in a mouth spray. Sativex is a synthetic mixture of THC and CBD in a 1:1 ratio. It has been shown to be safe and effective in controlling pain and muscle spasticity in MS.[18]

The evidence that CBD in oil or tincture form may benefit MS is mostly anecdotal. No clinical studies have been performed so far. The anecdotal information essentially boils down to “It works for some but not for others”. It may be worth a try but work with your physician and don’t try it on your own.

 

Evidence Based Use of CBD for Inflammation

CBD has been shown to have anti-inflammatory properties. A 2014 review indicated that in many mouse and rat studies, CBD had significant anti-inflammatory properties. [19]

In rat models of inflammatory arthritis, topical CBD reduced both inflammation and pain related behaviors. [20] In a mouse model of arthritis, CBD also reduced inflammation, but it was not clear how it was able to do this. [21] Other lab studies support this view. [22]

Overall, it is the same story. Anecdotally, CBD is believed to be effective at reducing inflammation. Clinical studies are lagging, but the studies that have been carried out using lab animals indicate that CBD reduces markers of inflammation. It is not yet clear how this happens. Again, the current evidence indicates that CBD can reduce inflammation and the pain often associated with it and is worth a try. The recommendations would include working with your physicians and starting at a low dose and slowly increasing the dose until you feel your goal has been reached.

 

Tips for Choosing a CBD Product for Pain

Always, always, always start at a low dose and slowly increase that dose until the pain has been effectively relieved. All the data indicates that CBD is safe over a wide range of doses but why buy or use more than you need?

We here at LeafReport are striving to help you make the best choice possible. The most important parameters to consider are:

  • Make certain of the purity of the product and that the label gives accurate information. The best way to do this is by ensuring that the company you are looking to buy from has a good, professional reputation AND that they use 3rd party labs to test their product to ensure both purity and accuracy. We have done many different company and product reviews so you don’t have to!
  • Human nature seems to want to have the most “potent” product around but you may not need that amount of product. You would be wasting money better spent on other needs. If you follow the adage “Start low and go slow” you will be able to determine your most effective dose. This may be quite different from your friend’s most effective dose so go through your own trial and error process to find it. You may, or may not, need to increase that dose, depending on your particular situation.
  • When you are dealing with pain, it can be difficult to be patient and the trial and error process does require some patience! If you are using a topical product for pain, apply it and give it at least 20-30 minutes to be effective and then slowly increase the amount if required. If you find you need to apply a further amount every thirty minutes or so, you can likely go to a more potent product. That may be one that is more highly concentrated or one that contains more total CBD. If you are taking CBD by mouth, you should wait at least 1-2 hours before trying the same dose and a few days before you try increasing the dose. Oral products take longer to show their effectiveness than topical products do but the effects last hours longer.

 

References Cited

  1. [1] Iffland, Kerstin, and Franjo Grotenhermen. “An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies.” Cannabis and cannabinoid research vol. 2,1 139-154. 1 Jun. 2017, doi:10.1089/can.2016.0034
  2. [2] Russo, Ethan B. “Cannabidiol claims and misconceptions.” Trends in pharmacological sciences 38.3 (2017): 198-201.
  3. [3] Mechoulam R; Parker LA., The endocannabinoid system and the brain. Annu Rev Psychol. 2013; 64:21-47.
  4. [4] de Mello Schier AR, et al, Antidepressant like and anxiolytic like effects of cannabidiol: a chemical compound of Cannabis sativa. CNS Neurol Disord Drug Targets. 2014;13(6):953-60.
  5. [5] Baylie, R L, and J E Brayden. “TRPV channels and vascular function.” Acta physiologica (Oxford, England) vol. 203,1 (2011)
  6. [6] Blessing, Esther M., et al. “Cannabidiol as a potential treatment for anxiety disorders.” Neurotherapeutics 12.4 (2015): 825-836.
  7. [7] Meng, Howard, et al. “Selective cannabinoids for chronic neuropathic pain: a systematic review and meta-analysis.” Anesthesia & Analgesia 125.5 (2017): 1638-1652.
  8. [8] Kress, Michaela, and R. Kuner. “Mode of action of cannabinoids on nociceptive nerve endings.” Experimental brain research 196.1 (2009): 79-88.
  9. [9] O’Brien, Melissa, and Jason J. McDougall. “Cannabis and joints: scientific evidence for the alleviation of osteoarthritis pain by cannabinoids.” Current opinion in pharmacology 40 (2018): 104-109.
  10. [10] Vučković, Sonja et al. “Cannabinoids and Pain: New Insights From Old Molecules.” Frontiers in pharmacology vol. 9 1259. 13 Nov. 2018, doi:10.3389/fphar.2018.01259
  11. [11] do Nascimento, Glauce Crivelaro, et al. “Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson’s disease.” Neuropharmacology (2019): 107808.
  12. [12] ElSohly MA, Radwan MM, Gul W, Chandra S, Galal A., Phytochemistry of Cannabis sativa L. Prog Chem Org Nat Prod. 2017; 103():1-36.
  13. [13] Mücke M, Phillips T, Radbruch L, Petzke F, Häuser W., Cannabis based medicines for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2018 Mar 7; 3():CD012182.
  14. [14] Andreae MH, Carter GM, Shaparin N, Suslov K, Ellis RJ, Ware MA, Abrams DI, Prasad H, Wilsey B, Indyk D, Johnson M, Sacks HS, Inhaled Cannabis for Chronic Neuropathic Pain: A Meta-analysis of Individual Patient Data. J Pain. 2015 Dec; 16(12):1221-1232.
  15. [15] NASEM (2017). National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Population Health and Public Health Practice; Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda. The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research. Washington, DC: National Academies Press
  16. [16] Shaw, Christian, L. L. C. Halcyon Therapeutics, and Jahan Marcu. “Cannabidiol in the Management of Comorbid Rheumatoid Arthritis, Lupus, and Raynaud’s Disease.” Endocannabinoid Medicine 2.30 (2016): 14.
  17. [17] Lowin, Torsten, Matthias Schneider, and Georg Pongratz. “Joints for joints: cannabinoids in the treatment of rheumatoid arthritis.” Current opinion in rheumatology 31.3 (2019): 271-278.
  18. [18] Zettl, Uwe K., et al. “Evidence for the efficacy and effectiveness of THC-CBD oromucosal spray in symptom management of patients with spasticity due to multiple sclerosis.” Therapeutic advances in neurological disorders 9.1 (2016): 9-30.
  19. [19] Burstein, Sumner. “Cannabidiol (CBD) and its analogs: a review of their effects on inflammation.” Bioorganic & medicinal chemistry 23.7 (2015): 1377-1385.
  20. [20] Hammell, D. C., et al. “Transdermal cannabidiol reduces inflammation and pain related behaviours in a rat model of arthritis.” European Journal of Pain 20.6 (2016): 936-948.
  21. [21] Zurier, Robert B., and Sumner H. Burstein. “Cannabinoids, inflammation, and fibrosis.” The FASEB Journal 30.11 (2016): 3682-3689.
  22. [22] Philpott, Holly T., Melissa O’brien, and Jason J. McDougall. “Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis.” Pain 158.12 (2017): 2442.
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About The Authors
Dr. Zora DeGrandpre practices naturopathic medicine (home visits) in rural Washington and is a professional medical and scientific writer and editor, specializing in naturopathic, functional, botanical and integrative medicine. Dr. DeGrandpre has degrees in drug design, immunology and natural medicine and has extensive research experience in cancer and molecular immunology. Dr DeGrandpre has found the use of CBD with elderly patients and others to be safe and clinically effective.
Gleb Oleinik
Gleb Oleinik
CBD Journalist
Gleb Oleinik is a CBD and health journalist from Vancouver, Canada. He’s read thousands of research studies about various supplement ingredients, enabling him to translate complex health information into simple language. Gleb specializes in CBD and has personally tried and reviewed dozens of CBD products. He’s knowledgeable about the ins and outs of the CBD industry as well as the science and research behind this popular natural remedy.
Leonard Haberman
Leonard Haberman
Physician & Chemist
Dr. Leonard Haberman is a physician and chemist who has been involved in solving chemical and medical problems for 43 years. He graduated from New York University as a dual major in chemistry and biology and went on to obtain a PhD in chemistry from the University of Minnesota where his focus was synthetic methods. He returned to the university in 2005, graduating with an MD degree in 2009. He has published in the open literature. He holds two patents and currently works as a consultant, assisting clients with projects within the disciplines of medicine and chemistry that have potential business applications.
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